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CFD modelling of two-phase stirred bioreaction systems by segregated solution of the Euler–Euler model

Elqotbi, Mohammed and Vlaev, S.D. and Montastruc, Ludovic and Nikov, Iordan CFD modelling of two-phase stirred bioreaction systems by segregated solution of the Euler–Euler model. (2013) Computers & Chemical Engineering, 48. 113-120. ISSN 0098-1354

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Official URL: http://dx.doi.org/10.1016/j.compchemeng.2012.08.005


An advanced study of a bioreactor system involving a Navier–Stokes based model has been accomplished. The model allows a more realistic impeller induced flow image to be combined with the Monod bioreaction kinetics reported previously. The time-course of gluconic acid production by Aspergillus niger strain is simulated at kinetic conditions proposed in the literature. The simulation is based on (1) a stepwise solution strategy resolving first the fluid flow field, further imposing oxygen mass transfer and bioreaction with subsequent analysis of flow interactions, and (2) a segregated solution of the model replacing the multiple iterations per grid cell with single iterations. The numerical results are compared with experimental data for the bioreaction dynamics and show satisfactory agreement. The model is used for assessment of the viscosity effect upon the bioreactor performance. A 10-fold viscosity rise results in 2-fold decrease of KLa and 25% decrease of the specific gluconic acid production rate. The model allows better understanding of the mechanism of the important bioprocess.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at Computers & Chemical Engineering website : http://dx.doi.org/10.1016/j.compchemeng.2012.08.005
HAL Id:hal-00919308
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Other partners > Bulgarian Academy of Sciences (BULGARIA)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Université des Sciences et Technologies de Lille - USTL (FRANCE)
Laboratory name:
Deposited On:05 Nov 2013 10:21

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