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Organosilylated complex [Eu(TTA)₃(Bpy-Si)]: a bifunctional moiety for the engeneering of luminescent silica-based nanoparticles for bioimaging

Duarte, Adriana P. and Mauline, Léïla and Gressier, Marie and Dexpert-Ghys, Jeannette and Roques, Christine and Caiut, José Maurício A. and Deffune, Elenice and Maia, Danielle C. G. and Carlos, Iracilda Z. and Ferreira, Antonio A. P. and Ribeiro, Sidney J. L. and Menu, Marie-Joëlle Organosilylated complex [Eu(TTA)₃(Bpy-Si)]: a bifunctional moiety for the engeneering of luminescent silica-based nanoparticles for bioimaging. (2013) Langmuir, 29 (19). 5878-5888. ISSN 0743-7463

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Official URL: http://dx.doi.org/10.1021/la400365c


A new highly luminescent europium complex with the formula [Eu(TTA)₃(Bpy-Si)], where TTA stands for the thenoyltrifluoroacetone, (C₄H3S)COCH₂COCF₃, chelating ligand and Bpy-Si, Bpy-CH₂NH(CH₂)₃(OEt)₃, is an organosilyldipyridine ligand displaying a triethoxysilyl group as a grafting function has been synthesized and fully characterized. This bifunctional complex has been grafted onto the surface of dense silica nanoparticles (NPs) and on mesoporous silica microparticles as well. The covalent bonding of [Eu(TTA)₃(Bpy-Si)] inside uniform Stöber silica nanoparticles was also achieved. The general methodology proposed could be applied to any silica matrix, allowed high grafting ratios that overcome chelate release and the tendency to agglomerate. Luminescent silica-based nanoparticles SiO₂-[Eu(TTA)₃(Bpy-Si)], with a diameter of 28 ± 2 nm, were successfully tested as a luminescent labels for the imaging of Pseudomonas aeruginosa biofilms. They were also functionalized by a specific monoclonal antibody and subsequently employed for the selective imaging of Escherichia coli bacteria.

Item Type:Article
HAL Id:hal-03523454
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Institut National des Sciences Appliquées de Toulouse - INSA (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP / São Paulo State University (BRAZIL)
Other partners > Universidade de São Paulo - USP (BRAZIL)
Laboratory name:
Deposited On:28 Oct 2013 13:24

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