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Le réseau micro-vasculaire structure la distribution de la pression sanguine

Guibert, Romain and Fonta, Caroline and Plouraboué, Franck Le réseau micro-vasculaire structure la distribution de la pression sanguine. (2009) Mécanique & Industries, 10 (3-4). 255-260. ISSN 1296-2139

(Document in English)

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Official URL: http://dx.doi.org/10.1051/meca/2009061


Cerebral micro-vascular networks control the blood pressure distribution when considering in vitro blood rheology models. Blood rheology is complex and non-linear. In small vessels, the effective viscosity variations are important due to red blood cells packing in capillaries, the so-called Fåhræus-Lindquist effect, whilst concomitantly phase segregation appears in bifurcations. Direct numerical simulations of different non-linear rheological models of the blood are performed on realistic three-dimensional micro-vascular networks. These simulations exhibit two significant results. First, various rheological models lead to very similar pressure distribution over the whole range of physiologically relevant hematocrits. Secondly, different models for phase segregation lead to very distinct hematocrit distributions in the micro-vacular network. Nevertheless, the hematocrit distribution very weakly affects the pressure distribution. Hence, our results suggest that the micro-vacular network structure mainly controls the pressure distribution in micro-circulation, whilst the effect of hematocrit distribution is weak.

Item Type:Article
Additional Information:Thanks to EDP Sciences editor. The definitive version is available at http://www.edpsciences.org The original PDF of the article can be found at Mécanique & Industries website : http://www.mecanique-industries.org/
HAL Id:hal-00844089
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
Deposited On:10 Jul 2013 09:55

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