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Biomimetic apatite-based biomaterials: on the critical impact of synthesis and post-synthesis parameters

Vandecandelaere, Nicolas and Rey, Christian and Drouet, Christophe Biomimetic apatite-based biomaterials: on the critical impact of synthesis and post-synthesis parameters. (2012) Journal of Materials Science: Materials in Medicine, 23 (11). 2593-2606. ISSN 0957-4530

(Document in English)

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Official URL: http://dx.doi.org/10.1007/s10856-012-4719-y


Nanocrystalline apatites are major constituents of hard tissues, and attempts are made worldwide to prepare synthetic analogs. However the impact of synthesis/ postsynthesis parameters is often disregarded. Based on an updated knowledge on such compounds, we inspected the effects of synthesis parameters (maturation time, temperature,pH, nature of counter-ions) and post-treatments (re-immersion in aqueous media, thermal treatment) on physicochemical characteristics. Great modifications were noticed during the 3 first days of maturation, where a progressive evolution of the apatite phase (localized in the core of the nanocrystals) toward stoichiometry was observed at the expense of the non-apatitic surface layer which progressively disappears. Similar trends were also evidenced for maturation run under increasing temperatures, studied here in the range 20–100 °C. pH impacted more specifically the chemical composition. The nature of the counter-ion in the starting phosphate salt influenced composition and nonstoichiometry, depending on its (in)ability to be incorporated in the lattice. Freeze-drying allowed to preserve a high surface reactivity, although further evolutions were noticed after re-immersion. Effects of a thermal treatment of dried samples were unveiled, suggesting a denaturation of the hydrated layer on the nanocrystals. This work underlines the necessity of a good control of synthesis/postsynthesis parameters for the production of biomimetic apatites.

Item Type:Article
Additional Information:Thanks to Springer editor. The definitive version is available at http://link.springer.com The original PDF of the article can be found at Journal of Materials Science : Materials in Medicine website : http://dx.doi.org/10.1007/s10856-012-4719-y
HAL Id:hal-03528026
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
Agence Nationale de la Recherche _ ANR
Deposited On:15 Jul 2013 09:36

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