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Progress on the preparation of nanocrystalline apatites and surface characterization: Overview of fundamental and applied aspects

Gómez-Morales, Jaime and Iafisco, Michele and Delgado-López, José Manuel and Sarda, Stéphanie and Drouet, Christophe Progress on the preparation of nanocrystalline apatites and surface characterization: Overview of fundamental and applied aspects. (2013) Progress in Crystal Growth and Characterization of Materials, 59 (1). 1-46. ISSN 0960-8974

(Document in English)

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Official URL: http://dx.doi.org/10.1016/j.pcrysgrow.2012.11.001


Nanocrystalline calcium phosphate apatites constitute the main inorganic part of hard tissues, and a growing focus is devoted to prepare synthetic analogs, so-called “biomimetic”, able to precisely mimic the morphological and physico-chemical features of biological apatite compounds. Both from fundamental and applied viewpoints, an accurate characterization of nanocrystalline apatites, including their peculiar surface features, and a deep knowledge of crystallization aspects are prerequisites to attempt understanding mineralization phenomena in vivo as well as for designing innovative bioactive materials that may then find applications in bone tissue engineering, either as self-supported scaffolds and fillers or in the form of coatings, but also in other domains such as drug delivery or else medical imaging. Also,interfacial phenomena are of prime importance for getting a better insight of biomineralization and for following the behavior of biomaterials in or close to their final conditions of use. In this view,both adsorption and ion exchange represent essential processes involving the surface of apatite nanocrystals, possibly doped with foreign elements or functionalized with organic molecules of interest. In this review paper, we will address these various points in details based on a large literature survey. We will also underline the fundamental physico-chemical and behavioral differences that exist between nanocrystalline apatites (whether of biological origin or their synthetic biomimetic analogs) and stoichiometric hydroxyapatite.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com/science/article/pii/S0960897412000332
HAL Id:hal-00857502
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Consejo Superior de Investigaciones Científicas - CSIC (SPAIN)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Other partners > Università di Bologna (ITALY)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Universidad de Granada - UGR (SPAIN)
Other partners > Università degli Studi del Piemonte Orientale-Amedeo Avogadro (ITALY)
Laboratory name:
Deposited On:12 Jul 2013 07:29

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