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On the normalization of cerebral blood flow

Guibert, Romain and Fonta, Caroline and Estève, François and Plouraboué, Franck On the normalization of cerebral blood flow. (2013) Journal of Cerebral Blood Flow & Metabolism, 33. 669-672. ISSN 0271-678X

(Document in English)

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Official URL: http://dx.doi.org/10.1038/jcbfm.2013.39


Cerebral blood flow (CBF) is the most common parameter for the quantification of brain’s function. Literature data indicate a widespread dispersion of values that might be related to some differences in the measurement conditions that are not properly taken into account in CBF evaluation. Using recent high-resolution imaging of the complete cortical microvasculature of primate brain, we perform extensive numerical evaluation of the cerebral perfusion. We show that blood perfusion associated with intravascular tracers should be normalized by the surface of the voxel rather than by its volume and we consistently test this result on the available literature data.

Item Type:Article
Additional Information:Thanks to Nature Publishing Group editor. The definitive version is available at www.nature.com/jcbfm/journal/v33/n5/full/jcbfm201339a.html
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > European Synchrotron Radiation Facility - ESRF (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
Deposited On:12 Jul 2013 09:39

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