Le Gal, Julien
and Michaud, Sandra and Gressier, Marie and Coulais, Yvon and Benoist, Eric
Synthesis, metal complexation and biological evaluation of a novel semi-rigid bifunctional chelating agent for 99mTc labelling.
(2006)
Bioorganic & Medicinal Chemistry, 1 (9). 2904-2909. ISSN 0968-0896
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(Document in English)
PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 227kB |
Official URL: http://dx.doi.org/10.1016/j.bmc.2005.12.005
Abstract
A novel bifunctional chelating agent bearing an aromatic ring has been synthesised and characterised. This ligand formed well-defined oxorhenium complexes. The analogous 99mTcO-complex was obtained in an excellent yield with high radiochemical purity (>95%). The biodistribution of the 99mTo-complex after intravenous injection studied in normal rats showed that the activity was excreted mainly via renal-urinary pathway indicating its use for labelling peptides with 99mTc.
| Item Type: | Article |
|---|---|
| Additional Information: | This publication is available on http://www.sciencedirect.com/science/journal/09680896 |
| HAL Id: | hal-03598118 |
| Audience (journal): | International peer-reviewed journal |
| Uncontrolled Keywords: | |
| Institution: | Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE) Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE) French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE) |
| Laboratory name: | |
| Statistics: | download |
| Deposited On: | 08 Sep 2008 07:08 |
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