Galgani, François and Cadiou, Yvon and Gilbert, Franck Simultaneous and iterative weighted regression analysis of toxicity tests using a microplate reader. (1992) Ecotoxicology and Environmental Safety, 23 (2). 237-243. ISSN 0147-6513
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Official URL: http://dx.doi.org/10.1016/0147-6513(92)90061-7
Abstract
A system is described for determination of LC50 or IC50 by an iterative process based on data obtained from a plate reader using a marine unicellular alga as a target species. The esterase activity of Tetraselmis suesica on fluorescein diacetate as a substrate was measured using a fluorescence titerplate. Simultaneous analysis of results was performed using an iterative process adopting the sigmoid function View the MathML source (dose of toxicant/IC50)slope for dose-response relationships. IC50 (± SEM) was estimated (P < 0.05). An application with phosalone as a toxicant is presented.
| Item Type: | Article |
|---|---|
| Audience (journal): | International peer-reviewed journal |
| Uncontrolled Keywords: | |
| Institution: | French research institutions > Institut Français de Recherche pour l'Exploitation de la MER - IFREMER (FRANCE) |
| Laboratory name: | |
| Statistics: | download |
| Deposited On: | 28 Sep 2012 11:35 |
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