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Characterization of the conglomerate form of acetyl-dl-leucine by thermal analysis and solubility measurements

Estime, Nicolas and Pena, Richard and Teychené, Sébastien and Autret, Jean Marie and Biscans, Béatrice Characterization of the conglomerate form of acetyl-dl-leucine by thermal analysis and solubility measurements. (2012) Journal of Crystal Growth, 342 (1). 28-33. ISSN 0022-0248

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Official URL: http://dx.doi.org/10.1016/J.JCRYSGRO.2011.03.023


Starting from a mixture of enantiomers in solution, crystallization can generate different types of crystals. In order to determine which type of crystal is obtained in the case of acetylleucine, an active pharmaceutical ingredient (API), analytical methods have been used to partially elucidate the binary and ternary phase diagrams of the system composed of the two enantiomers and water.The melting temperature phase diagram of this compound has been obtained by using differential scanning calorimetry (DSC) analyzes. The results show that it is characteristic of a conglomerate. This mode of crystallization has also been confirmed by X-ray powder diffraction analysis. Solubility measurements of enantiomerical mixtures in water enabled the determination of the ternary diagram of solubility. The empiric Meyerhoffer double solubility rule has been modified, due to the characterization of interactions between enantiomers.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at : http://www.sciencedirect.com/science/article/pii/S0022024811002958
HAL Id:hal-03536619
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Other partners > Laboratoires Pierre Fabre (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
Deposited On:03 Jul 2012 08:26

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