Badji, Boubekeur and Mostefaoui, Abdallah and Sabaou, Nasserdine and Mathieu, Florence and Lebrihi, Ahmed
Identification of a new strain of Actinomadura isolated
from Saharan soil and partial characterization of its
antifungal compounds.
(2011)
African Journal of Biotechnology, 10 (63). 13878-13886. ISSN 1684-5315
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(Document in English)
PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 617kB |
Official URL: http://dx.doi.org/10.5897/AJB11.999
Abstract
One promising strain Actinomadura sp. AC170, isolated from Algerian Saharan soil, with strong antifungal activity against pathogenic and toxinogenic fungi, was selected for further studies. The 16S rRNA results showed a distinct phylogenetic lineage from the other species within the Actinomadura genus. The production of antibiotic substances was investigated using GYEA solid medium. The butanolic extract contained four bioactive spots detected on thin layer chromatography plates. Among these antibiotics, a complex called 170A, which showed the more interesting antifungal activity, was selected and purified by reverse-phase HPLC. This complex is composed of four compounds. Ultraviolet-visible, infrared, mass and H nuclear magnetic resonance spectroscopy studies showed that these molecules contain an aromatic ring substituted by aliphatic chains. These compounds differ from the known antibiotics produced by Actinomadura species.
Item Type: | Article |
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Additional Information: | Thanks to Academic Journals editor. The definitive version is available at http://www.academicjournals.org The original PDF of the article can be found at : http://www.academicjournals.org/AJB/abstracts/abs2011/17Oct/Badji%20et%20al.htm |
HAL Id: | hal-03539461 |
Audience (journal): | International peer-reviewed journal |
Uncontrolled Keywords: | |
Institution: | French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE) Other partners > Ecole normale supérieure de Kouba (ALGERIA) Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE) Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE) |
Laboratory name: | Laboratoire de Recherche sur les Produits Bioactifs et la Valorisation de la Biomasse - LPBVB (Alger, Algeria) Laboratoire de Génie Chimique - LGC (Toulouse, France) - Bioprocédés et systèmes microbiens (BioSyM) |
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Deposited On: | 27 Jun 2012 07:55 |
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