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Structure-activity relationships of the N-methylcarbamate series in Salmonella typhimurium.

Narbonne, Jean-François and Cassand, Pierrette and Alzieu, P. and Grolier, P. and Merlina, Georges and Calmon, Jean-Pierre Structure-activity relationships of the N-methylcarbamate series in Salmonella typhimurium. (1987) Mutation Research Letters, 191 (1). 21-27. ISSN 0165-7992

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Official URL: http://dx.doi.org/10.1016/0165-7992(87)90165-5


Aromatic hydrocarbons of low molecular weight, hydroxy and N-methylcarbamate derivatives were tested for mutagenicity by the reversion of histidine-dependent Salmonella typhimurium TA98 and TA1535 in the presence of a rat-liver 9000 × g supernatant fraction. The presence of 2 or 3 aromatic rings resulted in a weak increase in revertants. Hydroxylation and carbamylation of aromatic rings increased the mutagenic activity of these aromatic compounds. In order to evaluate the structure-activity relationship, the specific molecular connectivity indices were calculated. A significant inverse relationship exist between mutagenicity and zero- and second-order specific molecular connectivity indices. Only compounds with second-order specific molecular connectivity indices lower than 0.300 increased mutagenic activity.

Item Type:Article
HAL Id:hal-03487086
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Other partners > Université de Bordeaux 1 (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
Deposited On:05 Apr 2013 07:25

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