Schwartz, Gary G. and Manderville, Richard A. and Pfohl-Leszkowicz, Annie
Response to Comments of Peter G. Mantle.
(2010)
Toxins, 2 (10). 2337-2339. ISSN 2072-6651
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(Document in English)
PDF (Publisher's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 138kB |
Official URL: http://dx.doi.org/10.3390/TOXINS2102337
Abstract
The apparently high yield of testis tumors (25%) in rats exposed long-term to Ochratoxin A (OTA) is uninterpretable without data on tumor yield in unexposed rats. Conversely, our demonstration that prenatal exposure to OTA induces DNA adducts in the testes of newborn mice and the absence of these adducts in the testes of mice not exposed prenatally to OTA, is evidence for the presumptive carcinogenicity of OTA in the testis. Together with recent data showing that prenatal exposure to OTA depresses expression of DMRT1, a tumor suppressor gene in the testis, our findings suggest that OTA may be a cause of testicular cancer.
| Item Type: | Article |
|---|---|
| Additional Information: | Thanks to MDPI editor. The definitive version is available at http://www.mdpi.com The original PDF of the article can be found at : http://www.mdpi.com/2072-6651/2/10/2337/htm |
| HAL Id: | hal-03548823 |
| Audience (journal): | International peer-reviewed journal |
| Uncontrolled Keywords: | |
| Institution: | French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE) Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE) Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE) Other partners > University of Guelph (CANADA) Other partners > Wake Forest University (USA) |
| Laboratory name: | Laboratoire de Génie Chimique - LGC (Toulouse, France) - Bioprocédés et systèmes microbiens (BioSyM) |
| Statistics: | download |
| Deposited On: | 31 May 2012 07:54 |
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