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Genotoxicity assay of chloral hydrate and chloropicrine

Giller, S. and Le Curieux, Franck and Gauthier, Laury and Erb, Françoise and Marzin, Daniel Genotoxicity assay of chloral hydrate and chloropicrine. (1995) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 348 (4). 147-152. ISSN 0027-5107

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Official URL: http://dx.doi.org/10.1016/0165-7992(95)90002-0


The chlorination by-products chloral hydrate and chloropicrine were assayed for genotoxicity in three short-term tests. Chloropicrine was 100-fold more potent than chloral in inducing mutations in strain TAI00 of S. typhimurium (fluctuation test) and, at variance with chloral, was positive in the SOS chromotest using strain PQ37 of E. coli. On the other hand, only chloral caused a significant increase in the frequency of micronucleated erythrocytes following in L, iL'o exposure of the amphibian Pleurodeles waltl newt larvae.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Institut Pasteur (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Université Lille 2, Droit et Santé (FRANCE)
Laboratory name:
Deposited On:01 Jun 2012 12:16

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