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High Zn content of Randall's plaque: A μ-X-ray fluorescence investigation

Carpentier, Xavier and Bazin, Dominique and Combes, Christèle and Mazouyes, Aurélie and Rouzière, Stephan and Albouy, Pierre-Antoine and Foy, Eddy and Daudon, Michel High Zn content of Randall's plaque: A μ-X-ray fluorescence investigation. (2011) Journal of Trace Elements in Medicine and Biology, 25 (3). 160-165. ISSN 0946-672X

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Official URL: http://dx.doi.org/10.1016/j.jtemb.2011.05.004


Kidney stone disease, or nephrolithiasis, is a common ailment. Among the different risk factors usually associated with nephrolithiasis are dehydration, metabolic defects (especially with regard to calcium and oxalate). The presence of a mineral deposit at the surface of the renal papilla (termed Randall's plaque) has all been recently underlined. Of note, Randall's plaque is made of the calcium phosphate, carbapatite, and serves as a nucleus for kidney stone formation. The process by which apatite nanocrystals nucleate and form Randall's plaque remains unclear. This paper deals with the possible relationship between trace elements and the formation of this mineral. The investigation has been performed on a set of Randall's plaques, extracted from human kidney stones, through μ-X-ray diffraction and μ-X-ray fluorescence analyses in order to determine the chemical composition of the plaque as well as the nature and the amount of trace elements. Our data provide evidence that Zn levels are dramatically increased in carbapatite of RP by comparison to carbapatite in kidney stones, suggesting that calcified deposits within the medullar interstitium are a pathological process involving a tissue reaction. Further studies, perhaps including the investigation of biomarkers for inflammation, are necessary for clarifying the role of Zn in Randall's plaque formation.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The orinal version is available at http://www.sciencedirect.com The original PDF of the article can be found at Journal of Trace Elements in Medicine and Biology website: http://www.sciencedirect.com/science/article/pii/S0946672X11000769
HAL Id:hal-03541380
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Commissariat à l'Energie Atomique et aux énergies alternatives - CEA (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Hôpital Pasteur (FRANCE)
Other partners > Assistance publique - Hôpitaux de Paris - AP-HP (FRANCE)
Other partners > Université Paris-Sud 11 (FRANCE)
Laboratory name:
Deposited On:06 Jun 2012 19:43

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