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Strontium-loaded mineral bone cements as sustained release systems : Compositions, release properties, and effects on human osteoprogenitor cells

Tadier, Solène and Bareille, Reine and Siadous, Robin and Marsan, Olivier and Charvillat, Cédric and Cazalbou, Sophie and Amédée, Joelle and Rey, Christian and Combes, Christèle Strontium-loaded mineral bone cements as sustained release systems : Compositions, release properties, and effects on human osteoprogenitor cells. (2012) Journal of Biomedical Materials Research Part B: Applied Biomaterials, 100B (2). 378-390. ISSN 1552-4973

(Document in English)

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Official URL: http://dx.doi.org/10.1002/jbm.b.31959


This study aims to evaluate in vitro the release properties and biological behavior of original compositions of strontium (Sr)-loaded bone mineral cements. Strontium was introduced into vaterite CaCO3-dicalcium phosphate dihydrate cement via two routes: as SrCO3 in the solid phase (SrS cements), and as SrCl2 dissolved in the liquid phase (SrL cements), leading to different cement compositions after setting. Complementary analytical techniques implemented to thoroughly investigate the release/dissolution mechanism of Sr-loaded cements at pH 7.4 and 37°C during 3 weeks revealed a sustained release of Sr and a centripetal dissolution of the more soluble phase (vaterite) limited by a diffusion process. In all cases, the initial burst of the Ca and Sr release (highest for the SrL cements) that occurred over 48 h did not have a significant effect on the expression of bone markers (alkaline phosphatase, osteocalcin), the levels of which remained overexpressed after 15 days of culture with human osteoprogenitor (HOP) cells. At the same time, proliferation of HOP cells was significantly higher on SrS cements. Interestingly, this study shows that we can optimize the sustained release of Sr2þ, the cement biodegradation and biological activity by controlling the route of introduction of strontium in the cement paste.

Item Type:Article
Additional Information:Thanks to John Wiley & Sons editor. The definitive version is available at http://onlinelibrary.wiley.com/ The original PDF of the article can be found at Journal of Biomedical Materials Research website: http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.31959/abstract;jsessionid=BF95F0C360C0BA0C27D2390516263D2B.d01t01
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Université de Bordeaux 2 - Victor Segalen (FRANCE)
Laboratory name:
Deposited On:15 May 2012 17:21

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