Guibert, Romain and Fonta, Caroline and Plouraboué, Franck
A New Approach to Model Confined Suspensions Flows
in Complex Networks: Application to Blood Flow.
(2010)
Transport in Porous Media, 83 (1). 171-194. ISSN 0169-3913
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(Document in English)
PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 762kB |
Official URL: http://dx.doi.org/10.1007/s11242-009-9492-0
Abstract
The modeling of blood flows confined in micro-channels or micro-capillary beds depends on the interactions between the cell-phase, plasma and the complex geometry of the network. In the case of capillaries or channels having a high aspect ratio (their longitudinal size is much larger than their transverse one), this modeling is much simplified from the use of a continuous description of fluid viscosity as previously proposed in the literature. Phase separation or plasma skimming effect is a supplementary mechanism responsible for the relative distribution of the red blood cell’s volume density in each branch of a given bifur- cation. Different models have already been proposed to connect this effect to the various hydrodynamics and geometrical parameters at each bifurcation. We discuss the advantages and drawbacks of these models and compare them to an alternative approach for modeling phase distribution in complex channels networks. The main novelty of this new formulation is to show that albeit all the previous approaches seek for a local origin of the phase segre- gation phenomenon, it can arise from a global non-local and nonlinear structuration of the flow inside the network. This new approach describes how elementary conservation laws are sufficient principles (rather than the complex arametric models previously proposed) to provide non local phase separation. Spatial variations of the hematocrit field thus result from the topological complexity of the network as well as nonlinearities arising from solving a new free boundary problem associated with the flux and mass conservation. This network model approach could apply to model blood flow distribution either on artificial micro-models, micro-fluidic networks, or realistic reconstruction of biological micro-vascular networks.
Item Type: | Article |
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Additional Information: | Thanks to Springer. The definitive version can be available at: http://www.springerlink.com/content/kj72721r5783638w/?MUD=MP |
HAL Id: | hal-03549125 |
Audience (journal): | International peer-reviewed journal |
Uncontrolled Keywords: | |
Institution: | French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE) Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE) Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE) |
Laboratory name: | |
Statistics: | download |
Deposited On: | 25 Apr 2012 12:58 |
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