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Co-grinding significance for calcium carbonate-calcium phosphate mixed cement. Part II: effect on cement properties

Tadier, Solène and Le Bolay, Nadine and Girod Fullana, Sophie and Cazalbou, Sophie and Charvillat, Cédric and Labarrère, Michel and Boitel, Daniel and Rey, Christian and Combes, Christèle Co-grinding significance for calcium carbonate-calcium phosphate mixed cement. Part II: effect on cement properties. (2011) Journal of Biomedical Materials Research Part B: Applied Biomaterials, 99B (2). 302-312. ISSN 1552-4973

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Official URL: http://dx.doi.org/10.1002/jbm.b.31899


In the present study, we aim to evaluate the contribution of the co-grinding process in controlling calcium carbonate-dicalcium phosphate dihydrate cement properties. We set a method designed to evaluate phase separation, usually occurring during paste extrusion, which is quantitative, reliable, and discriminating and points out the determining role of cogrinding to limit filter-pressing. We show that solid phase co-grinding leads to synergistic positive effects on cement injectability, mechanical properties, and radio-opacity. It allows maintaining a low (<0.4 kg) and constant load during the extrusion of paste, and the paste’s composition remains constant and close to that of the initial paste. Analogous behavior was observed when adding a third component into the solid phase, especially SrCO3 as a contrasting agent. Moreover, the cement’s mechanical properties can be enhanced by lowering the L/S ratio because of the lower plastic limit. Finally, unloaded or Sr-loaded cements show uniform and increased optical density because of the enhanced homogeneity of dry component distribution. Interestingly, this study reveals that cogrinding improves and controls essential cement properties and involves processing parameters that could be easily scaled up. This constitutes a decisive advantage for the development of calcium carbonate-calcium phosphate mixed cements and, more generally, of injectable multicomponent bone cements that meet a surgeon’s requirements.

Item Type:Article
Additional Information:Thanks to John Wiley & Sons editor. The definitive version is available at http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.31899/pdf
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Ecole nationale supérieure des Mines d'Albi-Carmaux - IMT Mines Albi (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Institut National des Sciences Appliquées de Toulouse - INSA (FRANCE)
Université de Toulouse > Institut Supérieur de l'Aéronautique et de l'Espace - ISAE-SUPAERO (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
Deposited On:13 Jan 2012 13:50

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