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The plant SDR superfamily : Involvement in primary and secondary metabolism

Tonfack, Libert Brice and Moummou, Hanane and Latché, Alain and Youmbi, Emmanuel and Benichou, Mohamed and Pech, Jean-Claude and Van der Rest, Benoît The plant SDR superfamily : Involvement in primary and secondary metabolism. (2011) Current Topics in Plant Biology, 12 . 41-53. ISSN 0972-4575

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Short-chain dehydrogenases/reductases (SDRs) comprise a large family of NAD(P)(H)-dependent oxidoreductases represented in plant kingdom by around 190 members in Arabidopsis. Here we will focus on the so-called ‘classical’ SDRs that account for about half of the SDRs and are characterized by a core structure of 250 amino acids and the conservations of specific motifs (cofactor binding site, catalytical residues). Although the ‘classical’ SDR family is highly divergent, an inventory of SDR from the model plant Arabidopsis thaliana genome reveals that it contains both large subfamilies with numerous members that share significant homologies (e.g. tropinone reductase, menthone/salutaridine reductase, NAD-dependent dehydrogenase) and small subfamilies with a limited number of members (e.g. protochlorophyllide reductase, β-ketoacyl-acyl carrier protein reductase and enoyl-reductase). The involvement of SDRs in plant metabolism illustrates the large functional diversity of the SDR superfamily’s members.Functions of SDR encompass many aspects of primary (lipid synthesis, chlorophyll biosynthesis or degradation) and secondary (terpenoids, steroids, phenolics and alkaloids) metabolism. The present paper aims at reviewing the metabolic functions where the role of SDR has been documented and at discussing their phylogenetic diversification and structural features.

Item Type:Article
HAL Id:hal-03472331
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
Other partners > Université de Yaoundé I (CAMEROON)
Other partners > University of Cadi Ayyad - UCAM (MOROCCO)
Laboratory name:
Deposited On:03 Oct 2011 13:19

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