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Validation of a manufacturing process of pellets for bone filling and drug delivery

Chevalier, Emilie and Viana, Marylène and Cazalbou, Sophie and Chulia, Dominique Validation of a manufacturing process of pellets for bone filling and drug delivery. (2008) Journal of Drug Delivery Science and Technology, 18 (6). 438-444. ISSN 1773-2247

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Wet high shear granulation followed by heat treatment was used to manufacture calcium phosphate porous spherical pellets. Experimental conditions were determined in order to obtain pellets presenting required specifications, i.e. size of about 800 μm, maximum sphericity and high microporosity. These pellets were intended for bone defect filling and in situ drug delivery and the final step therefore consisted in ibuprofen loading. In a context of quality assurance, the aim of the present work was to validate each step of the manufacturing process (i.e. granulation, calcination and drug loading). Indeed, reproducibility of the pellet characteristics, especially the drug content and release kinetics from the ceramic to be implanted, has to be ensured through the manufacture quality control.

Item Type:Article
HAL Id:hal-03477035
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Other partners > Université de Limoges - UNILIM (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
Deposited On:21 Jun 2011 10:34

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