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Characterisation of a non-pathogenic and non-protective infectious rabbit lagovirus related to RHDV

Le Gall-Reculé, Ghislaine and Zwingelstein, Françoise and Fages, Marie-Philippe and Bertagnoli, Stéphane and Gelfi, Jacqueline and Aubineau, Jacky and Roobrouck , Alain and Botti, Giuliana and Lavazza, Antonio and Marchandeau, Stéphane Characterisation of a non-pathogenic and non-protective infectious rabbit lagovirus related to RHDV. (2010) Virology, 410 (2). 395-402. ISSN 0042-6822

(Document in English)

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Official URL: http://dx.doi.org/10.1016/j.virol.2010.12.001


The existence of non-pathogenic RHDV strains was established when a non-lethal virus named rabbit calicivirus (RCV) was characterised in 1996 in Italy. Since then, different RNA sequences related to RHDV have been detected in apparently healthy domestic and wild rabbits, and recently a new lagovirus was identified in Australia. We have characterised from seropositive healthy domestic rabbits a non-lethal lagovirus that differs from RHDV in terms of pathogenicity, tissue tropism and capsid protein sequence. Phylogenetic analyses have revealed that it is close to the Ashington strain and to the RCV, but distinct. We proved experimentally that it is infectious but non-pathogenic and demonstrated that, contrary to the other described non-pathogenic lagoviruses, it induces antibodies that do not protect against RHDV. Our results indicate the existence of a gradient of cross-protection between circulating strains, from non-protective, partially protective to protective strains, and highlight the extent of diversity within the genus Lagovirus.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The original PDF of the article is available at http://bit.ly/o4bthN
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Other partners > Agence Nationale de Sécurité Sanitaire - ANSES (FRANCE)
Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE)
French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
Other partners > Instituto Zooprofilattico Sperimentale della Lombardia et dell' Emilia Romagna - IZSLER (ITALY)
Other partners > Office National de la Chasse et de la Faune Sauvage - ONCFS (FRANCE)
Laboratory name:
Deposited On:20 Jul 2011 14:00

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