Volmer, Romain and Nazel-Sanchez, Beryl and Volmer, Christelle and Soubiès, Sébastien and Guérin, Jean-Luc
Nucleolar localization of influenza A NS1: striking differences between mammalian and avian cells.
(2010)
Virology Journal, 7 (63). 2-5. ISSN 1743-422X
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(Document in English)
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 269kB |
Official URL: http://dx.doi.org/10.1186/1743-422X-7-63
Abstract
In mammalian cells, nucleolar localization of influenza A NS1 requires the presence of a C-terminal nucleolar localization signal. This nucleolar localization signal is present only in certain strains of influenza A viruses. Therefore, only certain NS1 accumulate in the nucleolus of mammalian cells. In contrast, we show that all NS1 tested in this study accumulated in the nucleolus of avian cells even in the absence of the above described C-terminal nucleolar localization signal. Thus, nucleolar localization of NS1 in avian cells appears to rely on a different nucleolar localization signal that is more conserved among influenza virus strains.
Item Type: | Article |
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Additional Information: | Thanks to BioMed Central editor. The original PDF of the article can be found at : http://dx.doi.org/10.1186/1743-422X-7-63 |
Audience (journal): | International peer-reviewed journal |
Uncontrolled Keywords: | |
Institution: | Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE) French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE) Other partners > University of St Andrews (UNITED KINGDOM) |
Laboratory name: | |
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Deposited On: | 23 May 2011 13:52 |
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