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Carbon nanotubes induce inflammation but decrease the production of reactive oxygen species in lung

Crouzier, David and Follot, S. and Gentilhomme, Edgar and Flahaut, Emmanuel and Arnaud, R. and Dabouis, Vincent and Castellarin, C. and Debouzy, Jean-Claude Carbon nanotubes induce inflammation but decrease the production of reactive oxygen species in lung. (2010) Toxicology, 272 (1-3). 39-45. ISSN 0300-483X

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Official URL: http://dx.doi.org/10.1016/j.tox.2010.04.001


With the rapid spread of carbon nanotubes (CNTs) applications, the respiratory toxicity of these compounds has attracted the attention of many scientists. Several studies have reported that after lung administration, CNTs could induce granuloma, fibrosis, or inflammation. By comparison with the mechanisms involved with other toxic particles such as asbestos, this effect could be attributed to an increase of oxidative stress. The aim of the present work was to test this hypothesis in vivo. Mice were intranasally instilled with 1.5 mg/kg of double walled carbon nanotubes (DWCNTs). Six, 24, or 48 h after administration, inflammation and localisation of DWCNTs in lungs were microscopically observed. Local oxidative perturbations were investigated using ESR spin trapping experiments, and systemic inflammation was assessed by measuring the plasma concentration of cytokines TNF-α, IL-1α, IL-1β, IL-6, IGF-1, Leptin, G-CSF, and VEGF. Examination of lungs and the elevation of proinflammatory cytokines in the plasma (Leptin and IL-6 at 6 h) confirmed the induction of an inflammatory reaction. This inflammatory reaction was accompanied by a decrease in the local oxidative stress. This effect could be attributed to the scavenger capability of pure CNTs.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at Toxicology website :http://www.sciencedirect.com/science/journal/0300483X
HAL Id:hal-03551062
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Other partners > Institut de Recherche Biomédicale des Armées - IRBA (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
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Deposited On:02 May 2011 13:50

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