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A Bovine Prion Acquires an Epidemic Bovine Spongiform Encephalopathy Strain-Like Phenotype on Interspecies Transmission

Béringue, Vincent and Andréoletti, Olivier and Le Dur, Annick and Essalmani, Rachid and Vilotte, Jean-Luc and Lacroux, Caroline and Reine, Fabienne and Herzog, Laëtitia and Biacabé, Anne-Gaëlle and Baron, Thierry and Caramelli, Maria and Casalone, Cristina and Laude, Hubert A Bovine Prion Acquires an Epidemic Bovine Spongiform Encephalopathy Strain-Like Phenotype on Interspecies Transmission. (2007) The Journal of Neuroscience, 2 (26). 6965-6971. ISSN 1529-2401

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Official URL: http://dx.doi.org/10.1523/JNEUROSCI.0693-07.2007


Implementation in Europe of large-scale testing to detect bovine spongiform encephalopathy (BSE)-infected cattle and prevent the transmission of this prion disease to humans has recently led to the discovery of novel types of bovine prions. We characterized atypical isolates called BSE L-type by analyzing their molecular and neuropathological properties during transmission to several mouse lines transgenic for the prion protein (PrP). Unexpectedly, such isolates acquired strain features closely similar to those of BSE-type agents when propagated in mice expressing ovine PrP, although they retained phenotypic traits distinct from BSE in other lines, including bovine PrP mice. These findings further underline the relationship between the crossing of species barrier and prion strain diversification, and, although the origin of the epidemic BSE agent has only been speculative until now, they provide new insight into the nature of the events that could have led to the appearance of this agent.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
Other partners > Istituto Zooprofilattico Sperimentale del Piemonte (ITALY)
Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE)
Other partners > Agence Française de Sécurité Sanitaire des Aliments - AFSSA (FRANCE)
Laboratory name:
Deposited On:13 Mar 2008 15:08

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