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Model Systems of Human Intestinal Flora, to Set Acceptable Daily Intakes of Antimicrobial Residues

Corpet, Denis E. Model Systems of Human Intestinal Flora, to Set Acceptable Daily Intakes of Antimicrobial Residues. (2000) Microbial Ecology in Health and Disease, 12 (1). 37-41. ISSN 0891-060X

(Document in English)

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Official URL: http://dx.doi.org/10.1080/08910600050216156


The veterinary use of antimicrobial drugs in food producing animals may result in residues in food, that might modify the consumer gut flora. This review compares three model systems that maintain a complex flora of human origin: (i) human flora associated (HFA) continuous flow cultures in chemostats, (ii) HFA mice, and (iii) human volunteers. The "No Microbial Effect Level" of an antibiotic on human flora, measured in one of these models, is used to set the accept¬able daily intake (ADI) for human consumers. Human volunteers trials are most relevant to set microbio¬log¬ical ADI, and may be considered as the "gold standard". However, human trials are very expensive and unethical. HFA chemostats are controlled systems, but tetracycline ADI calculated from a chemostat study is far above result of a human study. HFA mice studies are less expensive and better controlled than human trials. The tetracycline ADI derived from HFA mice studies is close to the ADI directly obtained in human volunteers.

Item Type:Article
Additional Information:Thanks to Informa Healthcare editor. The original PDF of the article is available at http://informahealthcare.com/doi/pdf/10.1080/08910600050216156
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE)
French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
Laboratory name:
Deposited On:06 Jan 2011 15:46

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