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Subchronic dietary exposure of rats to cadmium alters the metabolism of metals essential to bone health

Noël, Laurent and Guérin, Thierry and Kolf-Clauw, Martine Subchronic dietary exposure of rats to cadmium alters the metabolism of metals essential to bone health. (2004) Food and Chemical Toxicology, 42 (8). 1203-1210. ISSN 0278-6915

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Official URL: http://dx.doi.org/10.1016/j.fct.2004.02.017


Cadmium (Cd) was recently identified as a risk factor for osteoporosis. Skeletal damage may be the critical effect of low-level long-term exposure to Cd in the general population exposed via food, but the mechanisms behind this are not clearly understood.We investigated the effects of dietary Cd exposure on metals involved in bone turnover. Female rats received a Cd-supplemented diet (0, 10, 50, or 200 CdCl2 mg/kg diet) for 13 weeks. Cd and essential metals stored in the liver were measured by ICP-MS multianalysis. Mineral content of the livers was modified according to Cd level : iron, magnesium and selenium decreased while copper, zinc and manganese increased with increasing Cd levels. Iron was the most strikingly affected metal, falling to one-fifth of control values at high dietary Cd exposure. In this dosage group, selenium decreased to 36% of mean control concentrations while zinc increased to 168%. This mineral imbalance, especially depleted iron stores, can contribute, at least in part, to the Cd-associated risk of osteoporosis. The association between iron metabolism and Cd exposure should be investigated in humans, as Cd and low iron stores could act synergistically as risk factors for osteoporosis.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The original PDF of the article is available on Food and Chemical Toxicology website : http://www.sciencedirect.com/science/journal/02786915
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Other partners > Agence Française de Sécurité Sanitaire des Aliments - AFSSA (FRANCE)
Other partners > Ecole Nationale Vétérinaire d'Alfort - ENVA (FRANCE)
Laboratory name:
Deposited On:09 Dec 2010 08:39

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