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Reference values: a review

Geffré, Anne and Friedrichs, Kristen and Harr, Kendal and Concordet, Didier and Trumel, Catherine and Braun, Jean-Pierre Reference values: a review. (2009) Veterinary Clinical Pathology, 38 (3). 288-298. ISSN 0275-6382

(Document in English)

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Official URL: http://dx.doi.org/10.1111/j.1939-165X.2009.00179.x


Reference values are used to describe the dispersion of variables in healthy individuals. They are usually reported as population-based reference intervals (RIs) comprising 95% of the healthy population. International recommendations state the preferred method as a priori nonparametric determination from at least 120 reference individuals, but acceptable alternative methods include transference or validation from previously established RIs. The most critical steps in the determination of reference values are the selection of reference individuals based on extensively documented inclusion and exclusion criteria and the use of quality-controlled analytical procedures. When only small numbers of values are available, RIs can be estimated by new methods, but reference limits thus obtained may be highly imprecise. These recommendations are a challenge in veterinary clinical pathology, especially when only small numbers of reference individuals are available.

Item Type:Article
Additional Information:Thanks to Wiley-Blackwell editor. The original PDF of the article is available at http://onlinelibrary.wiley.com/doi/10.1111/j.1939-165X.2009.00179.x/pdf
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE)
Other partners > IDEXX Laboratories (CANADA)
French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
Other partners > University of Wisconsin - Madison (USA)
Laboratory name:
Deposited On:03 Nov 2010 15:36

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