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Comparison of low-shear and high-shear granulation processes: effect on implantable calcium phosphate granule properties

Chevalier, Emilie and Viana, Marylène and Cazalbou, Sophie and Chulia, Dominique Comparison of low-shear and high-shear granulation processes: effect on implantable calcium phosphate granule properties. (2009) Drug Development and Industrial Pharmacy, 35 (10). 1255-1263 . ISSN 1520-5762

(Document in English)

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Official URL: http://dx.doi.org/10.1080/03639040902882298


Calcium phosphate porous ceramics present a great interest not only as complex bone defect fillers but also as drug delivery systems. Most of the methods described in the literature to fabricate pellets are based on compaction, casting into spherical molds, or on processes such as liquid immiscibility or foaming. Despite wet granulation is used in a wide range of applications in pharmaceuticals, food, detergents, fertilizers, and minerals, it is not applied in the biomaterial field to produce granules. Methods: In this study physicochemical and in vitro drug delivery properties of implantable calcium phosphate granules, produced by two wet agglomeration processes, were compared. Pellets obtained by high shear granulation (granulation in a Mi-Pro apparatus) were shown to be more spherical and less friable than granules elaborated by low shear process (granulation in a Kenwood apparatus). Although Mi-Pro pellets had a slightly lower porosity compared to Kenwood granules, ibuprofen loading efficiency and dissolution profiles were not statistically different and the release mechanism was mainly controlled by diffusion, in both cases. Conclusion: Mi-Pro pellets appeared to be better candidates as bone defect fillers and local drug delivery systems as far as they were more spherical and less friable than Kenwood agglomerates.

Item Type:Article
Additional Information:Thanks to Informa Healthcare editor. The definitive version is available at http://informahealthcare.com/ The original PDF of the article can be found at Drug Development and Industrial Pharmacy website : http://www.informaworld.com/smpp/content~content=a911042023~db=all~jumptype=rss
HAL Id:hal-00429400
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Other partners > Université de Limoges - UNILIM (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Laboratory name:
Deposited On:12 Apr 2011 13:43

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