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Comparative efficacy of two fipronil spot-on formulations against experimental flea infestations (Ctenocephalides felis) in dogs

Bonneau, Stéphane and Fourier, Josephus J and Rousseau, Carine and Cadiergues, Marie-Christine Comparative efficacy of two fipronil spot-on formulations against experimental flea infestations (Ctenocephalides felis) in dogs. (2010) International Journal of Applied Research in Veterinary Medicine, 8 (1). 16-20. ISSN 1559-4602

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A new fipronil-based spot-on formulation applied once to dogs was evaluated against experimental flea infestations in a parallel group design, randomized, unicentre and blinded controlled study. Eight dogs served as negative controls (group 1), eight dogs were treated with a 10% w/v fipronil-based spot-on solution (Effipro® Spot-on, Virbac SA) at a dosage of 0.67 mL for a dog weighing from 2 to 10 kg and 1.34 mL for a dog weighing from 10.1 to 20 kg (group 2) and eight dogs served as positive controls (group 3) receiving the original fipronil spot-on (Frontline® Top spot, Merial) at a similar dosage. Each dog was infested with 100 unfed adult Ctenocephalides felis on days -6, -1, 7, 14, 21, 28, 35, 42, 49, 56, 63, 70, 77, 84 and 91. At 48 h after treatment or re-infestation, each dog was combed to remove and count live fleas. Geometric mean flea counts obtained were reduced by 99.7 and 100% in groups 2 and 3, respectively on day 2, compared to the negative control group. Dogs were protected from re-infestations with an efficacy >95 per cent for 93 days in group 2 and for 79 days in group 3. Both 10% w/v fipronil-based spot-ons, despite different vehicles, were equally able to eradicate flea infestation, to prevent new infestations and were well-tolerated.

Item Type:Article
Additional Information:L'éditeur n'autorise pas la mise en ligne du document.
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE)
Other partners > ClinVet International (SOUTH AFRICA)
Other partners > Virbac SA (FRANCE)
Laboratory name:
Département Sciences Cliniques des animaux de compagnie et de sport (Toulouse, France) - Groupe de Recherche Animaux de Compagnie - Dermatologie
Deposited On:01 Jun 2010 12:20

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