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Testing the efficacy of medium chain fatty acids against rabbit colibacillosis

Gallois, Mélanie and Gidenne, Thierry and Orengo, Juan and Caubet, Cécile and Tasca, Christian and Milon, Alain and Boullier, Séverine Testing the efficacy of medium chain fatty acids against rabbit colibacillosis. (2008) Veterinary Microbiology, 1. 192-198. ISSN 0378-1135

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Official URL: http://dx.doi.org/10.1016/j.vetmic.2008.03.004


Enteropathogenic Escherichia coli (EPEC) represents a major cause of lethal diarrhea in young mammals. Although the pathogenicity mechanisms of EPEC are now well understood, the intrinsic and environmental factors that control the expression of EPEC virulence remain largely unknown. In the rabbit, suckling reduces pups’ sensitivity to EPEC infection. Hence, we have hypothesized that uncharacterized factors present in doemilkmay mediate this protection. Medium chain fatty acids (MCFA), known to possess antimicrobial properties, are highly abundant in doe milk.We demonstrate that caprylic acid exhibits a clear bacteriostatic effect in vitro against the rabbit EPEC strain E22 (O103:H2:K-), in a dose-dependent manner. In vivo, the dietary inclusion of triglycerides of MCFA did not however reduce the sensitivity of young rabbits challenged with this EPEC strain. The mortality and fecal excretion of EPEC were not reduced, and the bacterial adhesion to ileum was not inhibited. Amount of MCFA reaching the ileal level might have been too low and/or their association to other milk antimicrobials may have been required to observe a positive effect on disease evolution in a context of a highly virulent challenge.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.elsevier.com/wps/find/journaldescription.cws_home/503320/description#description
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE)
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Deposited On:21 May 2010 11:40

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