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Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats

Saillenfait, Anne-Marie and Gallissot, Frédéric and Sabaté, Jean-Philippe and Bourges-Abella, Nathalie and Cadot, R. and Morel, G. and Lambert, A.M. Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats. (2006) Food and Chemical Toxicology, 4 (8). 1287-1298. ISSN 0278-6915

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Official URL: http://dx.doi.org/10.1016/j.fct.2006.02.006


Pregnant Sprague–Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000 ppm) and methylethylketone (MEK; 0, 1000, or 3000 ppm), alone and in combination, by inhalation, for 6 h/day, during days 6–20 of gestation. Maternal toxicity, evidenced by decreased in body weight gain and food consumption, tended to be greater after simultaneous exposures to the high concentrations of 1000 ppm EB and 3000 ppm MEK, when compared to the treatments with individual compounds. No significant increase in embryo/fetal lethality or incidence of malformations and variations was observed in any of the treatment groups. Fetal body weight was significantly reduced after individual treatment with 1000 ppm EB or 3000 ppm MEK, and in the combined groups. There was no evidence of interaction between EB and MEK in causing developmental toxicity.

Item Type:Article
Additional Information:Thanks to Elsevier ScienceDirect. The original PDF of the article can be found at the Food and Chemical Toxicology website : http://www.sciencedirect.com/science/journal/02786915
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Other partners > Institut National de Recherche et Sécurité - INRS (FRANCE)
Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE)
Other partners > Institut Universitaire de Médecine du Travail (FRANCE)
Laboratory name:
Deposited By: Mathieu Andro
Deposited On:06 May 2008 14:30

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