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Preparation, physical-chemical characterisation and cytocompatibility of calcium carbonate cements

Combes, Christèle and Miao, Baoji and Bareille, Reine and Rey, Christian Preparation, physical-chemical characterisation and cytocompatibility of calcium carbonate cements. (2006) Biomaterials, 27 (9). 1945-1954. ISSN 0142-9612

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Official URL: http://dx.doi.org/10.1016/j.biomaterials.2005.09.026


The feasibility of calcium carbonate cements involving the recrystallisation of metastable calcium carbonate varieties has been demonstrated. Calcium carbonate cement compositions presented in this paper can be prepared straightforwardly by simply mixing water (liquid phase) with two calcium carbonate phases (solid phase) which can be easily obtained by precipitation. An original cement composition was obtained by mixing amorphous calcium carbonate and vaterite with an aqueous medium. The cement set and hardened within 2 hours at 37°C in an atmosphere saturated with water and the final composition of the cement consisted mostly of aragonite. The hardened cement was microporous and showed poor mechanical properties. Cytotoxicity tests revealed excellent cytocompatibility of calcium carbonate cement compositions. Calcium carbonates with a higher solubility than the marketed calcium phosphate cements might be of interest to increase biomedical cement resorption rates and to favour its replacement by bone tissue.

Item Type:Article
Additional Information:The original publication is available on http://www.sciencedirect.com/science/journal/01429612
HAL Id:hal-03599512
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Laboratory name:
Deposited On:06 Feb 2008 16:47

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