Casas-Cabanas, Montse and Comtat, Maurice and Gros, Pierre
and Redoules, Daniel and Ruffien-Ciszak, Audrey
and Schmitt, Anne-Marie and Questel, Emmanuel
Exploration of the global antioxidant capacity of the stratum corneum by cyclic voltammetry.
(2006)
Journal of Pharmaceutical and Biomedical Analysis, 40 (1). 162-167. ISSN 0731-7085
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(Document in English)
PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 238kB |
Official URL: http://dx.doi.org/10.1016/j.jpba.2005.05.035
Abstract
Cyclic voltammetry is proposed as a new method for evaluating the antioxidant capacity of skin based on the reducing properties of low molecular weight antioxidants (LMWA). Experiments were performed simply by recording the anodic current at 0.9 V/SCE of a platinum microelectrode placed directly on the epidermis surface without any gel or water. This method ensured a direct, rapid (less than 1 min), reliable (accuracy 12%) and non-invasive measurement of the global antioxidant capacity of the stratum corneum with a high spatiotemporal resolution. At the same time, the pH of the skin surface was determined by recording the cathodic current at 0 V/SCE. Based on an exploratory study involving nine volunteer subjects, the evolution of the amperometric response of the microelectrode with time revealed a periodic modification of the redox properties.
Item Type: | Article |
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Additional Information: | This article is available at http://www.sciencedirect.com/science/article/pii/S0731708505004401 |
HAL Id: | hal-03595123 |
Audience (journal): | International peer-reviewed journal |
Uncontrolled Keywords: | |
Institution: | Other partners > Laboratoires Pierre Fabre (FRANCE) Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE) Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE) French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE) |
Laboratory name: | Laboratoire de Génie Chimique - LGC (Toulouse, France) - Procédés électrochimiques (PE) Centre de Recherche sur la Peau (Toulouse, France) |
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Deposited On: | 23 Jul 2009 09:06 |
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