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Mechanical properties of fused sagittal sutures in scaphocephaly

Swider, Pascal and Delanoé, Franck and Jalbert, Florian and Boetto, Sergio and Assemat, Pauline and Estivalèzes, Erik and Lauwers, Frédéric Mechanical properties of fused sagittal sutures in scaphocephaly. ( In Press: 2021) Clinical Biomechanics. 105369. ISSN 0268-0033

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Official URL: https://doi.org/10.1016/j.clinbiomech.2021.105369

Abstract

Background: Craniosynostosis in newborns is caused by the premature closure of the cranial sutures leading to cranial vault deformity. It results in aesthetic imbalance and developmental disabilities and surgery is frequent during the first months of growth. Our study focused on scaphocephaly defined as the premature closure of the sagittal suture. We hypothesised that the effective mechanical properties of sutures were altered as compared to those of the parietal adjacent tissue considered as control. Methods: The population consisted of seven males and four females (mean age 4.9 months). Sixteen suture samples and thirty-four parietal tissue samples were harvested during corrective surgery and investigated by using three-point bending tests to obtain the structure-stiffness of specimens. An energy model was used to derive the effective Young’s modulus. A histological study complemented the experimental protocol. Findings: Fused sutures were thicker than adjacent bone and the natural curvature of sutures did not influence the static mechanical response. The stiffness of stenotic sutures was significantly higher than that of the parietal bone. The effective Young’s modulus of stenotic sutures was significantly lower than that of the parietal adjacent tissue. The parietal tissue showed a parallel bone architecture whereas the central stenotic tissue was disorganised with more vascularisation. Interpretation: The stenotic suture differed in structural and mechanical terms from the adjacent bone during calvarial growth in the first year of life. Our study emphasised the alteration of effective tissue properties in craniosynostosis. Keywords: scaphocephaly, craniosynostosis, biomechanics, mechanobiology, paediatrics, morphogenesis.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
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Deposited On:30 Apr 2021 10:22

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