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VITAE : VIrTual brAin pErfusion

Sauvé, Alexandre and Julien, Jean-Daniel and Berg, Maxime and Peyrounette, Myriam and Elyakime, Pierre and Davit, Yohan and Pigou, Maxime and Lorthois, Sylvie VITAE : VIrTual brAin pErfusion. (2020) In: JCAD 2020 (Journées Calcul Données), 2 December 2020 - 4 December 2020 (Dijon, France).

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Official URL: https://jcad2020.sciencesconf.org/resource/page/id/7

Abstract

VITAE is an ERC funded software project aimed at providing full brain simulations of cerebral blood flow and solute exchange between blood and the neural tissue. The endgoal is to understand fine scale interactions between the architecture of the microvascular network in the brain and its functions (blood supply, oxygen and nutrient delivery, waste removal). This may indeed help unveil potential causes of cerebral disease like Alzheimer’s Disease. In the actual state of the art, full scale brain simulations are something new. First, acquiring input anatomical data of the blood vessel network is difficult and is an active domain of research. Next, simulation by itself is a CPU intensive Computational Fluid Dynamic problem requiring both inversion of large matrices and manipulation of large amounts of data. The current milestone is capable of running pressure resolution in a full mouse brain composed of about 5 millions of microvessels in one second on 1024 processor cores. The software written in C++ fully supports parallelized IO and graph partitioning to optimize the placement of vertices and reduce computing times. The next challenge is to run simulations taking the complex behavior of blood into account, which requires to run the pressure solver from one hundred to several thousand times. This will require to improve significantly the convergence time. Acknowledgements: ERC Funded Project: Proof of Concept (PoC), ERC-2018-PoC A. Sauvé, J.-D. Julien, M. Berg, M. Peyrounette, P. Elyakime, Y. Davit, M. Pigou, S. Lorthois

Item Type:Conference or Workshop Item (Other)
Audience (conference):National conference without published proceedings
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
Funders:
ERC POC VITAE (GA 825829)
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Deposited On:18 Mar 2021 18:14

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