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Polyanionic Hydrogels as Reservoirs for Polycationic Antibiotic Substitutes Providing Prolonged Antibacterial Activity

Gribova, Varvara and Boulmedais, Fouzia and Dupret Bories, Agnès and Calligaro, Cynthia and Senger, Bernard and Vrana, Nihal Engin and Lavalle, Philippe Polyanionic Hydrogels as Reservoirs for Polycationic Antibiotic Substitutes Providing Prolonged Antibacterial Activity. (2020) ACS Applied Materials and Interfaces, 12 (17). 19258-19267. ISSN 1944-8244

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Official URL: https://doi.org/10.1021/acsami.9b23140

Abstract

Implantation of biomedical devices is often followed by bacterial infections that may seriously affect implant functionalities and lead to their failure. In the context of bacterial resistance to antibiotics, which is a growing problem worldwide, new strategies that are able to overcome these problems are needed. In this work, we introduce a new formulation of hyaluronic acid (HA)-based antimicrobial material: HA hydrogels loaded with polyarginine (PAR), a polycationic antibiotic substitute. The loading is possible through electrostatic interactions between negatively charged HA and positively charged PAR. Such hydrogels absorb high quantities of PAR, which are then gradually released from the hydrogel. This original system provides a long-lasting antibacterial effect on an in vitro model of repetitive infection, thus demonstrating a strong potential to fight multiple rounds of infections that are resistant to antibiotic treatment. In addition, HA-PAR hydrogels could be deposited onto/into medical devices such as wound dressings and mesh prostheses used in clinical applications. Finally, we performed first in vivo tests of hydrogel-coated mesh materials to verify their biocompatibility in a rat model, which show no difference between control HA hydrogel and PAR-loaded hydrogel in terms of inflammation.

Item Type:Article
HAL Id:hal-03205670
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Other partners > Institut Claudius Regaud - ICR (FRANCE)
Other partners > Spartha medical (FRANCE)
Laboratory name:
Funders:
European Union’s Horizon 2020 PANBioRA research and innovation program under grant agreement no. 760921 - European Regional Development Fund (ERDF) in the framework of the INTERREG V Upper Rhine program “Transcending borders with every project”
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Deposited On:22 Apr 2021 12:50

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