OATAO - Open Archive Toulouse Archive Ouverte Open Access Week

Brushite (Ca,M)HPO4, 2H2O doping with bioactive ions (M = Mg2+, Sr2+, Zn2+, Cu2+, and Ag+): a new path to functional biomaterials?

Sayahi, Moufida and Santos, Jerran and El-Feki, Hafed and Charvillat, Cédric and Bosc, Françoise and Karacan, Ipek and Milthorpe, Bruce and Drouet, Christophe Brushite (Ca,M)HPO4, 2H2O doping with bioactive ions (M = Mg2+, Sr2+, Zn2+, Cu2+, and Ag+): a new path to functional biomaterials? (2020) Materials Today Chemistry, 16. 100230. ISSN 2468-5194

[img]
Preview
(Document in English)

PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
4MB

Official URL: https://doi.org/10.1016/j.mtchem.2019.100230

Abstract

Abstract Dicalcium phosphate dihydrate, DCPD (CaHPO4.2H2O),brushite, is an important CaP compound encountered in mineralized tissues and used in medicine, especially in bone cement formulations. However,the use of DCPD as direct implantable biomaterial has not received dedicated attention. Also, the possibility to dope DCPD with biologically-active ions to modulate its performances wasnot systematically explored. We have investigated in depth the dopingof DCPD with Mg2+, Sr2+, Zn2+, Cu2+and Ag+ions.Clear modifications interms of chemical composition, particle size, pore distribution, crystal morphology and affinity for waterwere pointed out. Then, the samples were cultured with human adipose-derived stem cells (ADSCs) to explore cytotoxicity and proliferation. Various behaviors were noticed dependent on the incorporated metal ions. Such DCPD compounds associated with bioactive metal ions, and particularly Ag+and Zn2+, appear promising as a new family of reactive materials for use, as such or in combination, in bone-related applications.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > University of Technology, Sydney - UTS (AUSTRALIA)
Other partners > Université de Sfax (TUNISIA)
Laboratory name:
Statistics:download
Deposited On:08 Feb 2021 14:29

Repository Staff Only: item control page