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Two Dimensional Oblique Molecular Packing within a Model Peptide Ribbon Aggregate

Kuczera, Stefan and Rüter, Axel and Roger, Kevin and Olsson, Ulf Two Dimensional Oblique Molecular Packing within a Model Peptide Ribbon Aggregate. (2020) ChemPhysChem, 21 (14). 1519-1523. ISSN 1439-4235

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Official URL: https://doi.org/10.1002/cphc.201901126

Abstract

A10K (A=alanine, K=lysine) model peptides self‐assemble into ribbon‐like β‐sheet aggregates. Here, we report an X‐ray diffraction investigation on a flow‐aligned dispersion of these self‐assembly structures. The two‐dimensional wide‐angle X‐ray scattering pattern suggests that peptide pack in a two‐dimensional oblique lattice, essentially identical to the crystalline packing of polyalanine, An (for n>4). One side of the oblique unit cell, corresponding to the anti‐parallel β‐sheet, is oriented along the ribbon's axis. Together with recently published small angle X‐ray scattering data of the same system, this work thus yields a detailed description of the self‐assembled ribbon aggregates, down to the molecular length scale. Notably, our results highlight the importance of the crystalline peptide packing within its self‐assembly aggregates, which is often neglected.

Item Type:Article
Additional Information:The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited,the use is non-commercial and no modifications or adaptations are made.
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Lund University (SWEDEN)
Other partners > Göteborgs Universitet (SWEDEN)
Laboratory name:
Funders:
Knut and Alice Wallenberg Foundation
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Deposited On:18 Jan 2021 14:14

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