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Effect of silver and strontium incorporation route on hydroxyapatite coatings elaborated by rf-SPS

Chambard, Marine and Remache, Djamel and Balcaen, Yannick and Dalverny, Olivier and Alexis, Joël and Siadous, Robin and Bareille, Reine and Catros, Sylvain and Fort, Pascal and Grossin, David and Gitzhofer, François and Bertrand, Ghislaine Effect of silver and strontium incorporation route on hydroxyapatite coatings elaborated by rf-SPS. (2020) Materialia, 12. 1-12. ISSN 2589-1529

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Official URL: https://doi.org/10.1016/j.mtla.2020.100809

Abstract

Hydroxyapatite coatings have been currently used on hip prostheses for their ability to promote faster osseointe- gration and bone growth. Nevertheless, post-operative infections remain a recurring problem. To overcome this issue, doping with antibacterial elements has become a new trend. In this work, hydroxyapatite coatings elab- orated by radio-frequency suspension plasma spraying (rf-SPS) were doped with silver and strontium. Several doping strategies were explored thanks to the versatility offered by SPS compared with conventional spraying. First way: calcium phosphate doped powders were synthesized by coprecipitation and then dispersed into water before plasma spraying; second way: undoped powder was dispersed into aqueous medium in which nitrates or nanoparticles of the dopant(s) were respectively dissolved/dispersed. XRD revealed a high level of crystallinity ratio (ISO 13 779) and hydroxyapatite proportion for most of the coatings, with the presence of Ag/Ag 2 O nanopar- ticles whatever the doping route. SEM-EDS and STEM have demonstrated a more homogeneous distribution of the strontium within the coating made from the doped powder. Adherence of the coatings was estimated via a 3-point bending test, while bacteriological tests with S. aureus and proliferation of mesenchymal stem cells (hMSC) were performed. The results indicated a preferential incorporation of strontium into the secondary phases, showed efficient bactericidal properties, excellent mechanical properties in comparison with an APS reference coating, and no evidence of cytotoxic effect. This opens the way of a new type of coatings with a finer structure and a higher homogeneity through a better control of physicochemical properties using a suspension as the precursor.

Item Type:Article
HAL Id:hal-03218463
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Projection Plasma Système - 2PS (FRANCE)
Other partners > Université de Bordeaux (FRANCE)
Other partners > Université de Sherbrooke (CANADA)
Laboratory name:
Funders:
ANR - Région Occitanie in France
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Deposited On:08 Jan 2021 14:54

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