Moreno, Adel and Quintard, Michel
and Mancini, Anthony
and Gomez-Brouchet, Anne and Swider, Pascal
and Assemat, Pauline
Upscaling of fluid flow in spatially heterogeneous bone tumors.
(2020)
In: VPH 2020 Conference, 26 August 2020 - 28 August 2020 (Paris, France).
(Unpublished)
|
(Document in English)
PDF (Publisher's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 1MB |
Abstract
Osteosarcoma is a malignant bone tumor that preferentially arises in adolescents and young adults. Like many sarcomas with complex genomics, this type of tumors exhibits strong spatial heterogeneities in terms of micro-architecture or differentiated response to treatments due to localized effect of chemotherapy. Clinical images at a tissue scale such as histological and immunohistological sections, exhibit three phases: fluid, solid, cells populations. Therefore the tumor can be considered as a porous medium. The objective of this work was to develop a mechanical approach based on upscaling methods to study the interstitial flow within the tumor at the tissue scale. The statistical study of the micro-architecture of the media shows that the identification of characteristic lengths is complex and that a separation of spatial scales is not necessarily identified. We therefore chose a special sequential upscaling technique, named Grid-Block approach to solve this problem.
Item Type: | Conference or Workshop Item (Poster) |
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HAL Id: | hal-03113650 |
Audience (conference): | International conference without published proceedings |
Uncontrolled Keywords: | |
Institution: | French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE) Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE) Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE) Other partners > Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE) |
Laboratory name: | |
Statistics: | download |
Deposited On: | 06 Jan 2021 13:34 |
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