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Upscaling of fluid flow in spatially heterogeneous bone tumors

Moreno, Adel and Quintard, Michel and Mancini, Anthony and Gomez-Brouchet, Anne and Swider, Pascal and Assemat, Pauline Upscaling of fluid flow in spatially heterogeneous bone tumors. (2020) In: VPH 2020 Conference, 26 August 2020 - 28 August 2020 (Paris, France). (Unpublished)

(Document in English)

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Osteosarcoma is a malignant bone tumor that preferentially arises in adolescents and young adults. Like many sarcomas with complex genomics, this type of tumors exhibits strong spatial heterogeneities in terms of micro-architecture or differentiated response to treatments due to localized effect of chemotherapy. Clinical images at a tissue scale such as histological and immunohistological sections, exhibit three phases: fluid, solid, cells populations. Therefore the tumor can be considered as a porous medium. The objective of this work was to develop a mechanical approach based on upscaling methods to study the interstitial flow within the tumor at the tissue scale. The statistical study of the micro-architecture of the media shows that the identification of characteristic lengths is complex and that a separation of spatial scales is not necessarily identified. We therefore chose a special sequential upscaling technique, named Grid-Block approach to solve this problem.

Item Type:Conference or Workshop Item (Poster)
HAL Id:hal-03113650
Audience (conference):International conference without published proceedings
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
Laboratory name:
Deposited On:06 Jan 2021 13:34

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