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Surface Zwitterionization of Expanded Poly(tetrafluoroethylene) via Dopamine-Assisted Consecutive Immersion Coating

Fowler, Peter Matthew Paul T. and Dizon, Gian Vincent and Tayo, Lemmuel L. and Caparanga, Alvin R. and Huang, James and Zheng, Jie and Aimar, Pierre and Chang, Yung Surface Zwitterionization of Expanded Poly(tetrafluoroethylene) via Dopamine-Assisted Consecutive Immersion Coating. (2020) ACS Applied Materials and Interfaces, 12 (37). 41000-41010. ISSN 1944-8244

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Official URL: https://doi.org/10.1021/acsami.0c09073

Abstract

Expanded polytetrafluoroethylene (ePTFE) is one of thematerials widely used in the biomedicalfield, yet its application is being limitedby adverse reactions such as thrombosis when it comes in contact with blood.Thus, a simple and robust way to modify ePTFE to be biologically inert issought after. Modification of ePTFE without high-energy pretreatment, such asimmersion coating, has been of interest to researchers for its straightforwardprocess and ease in scaling up. In this study, we utilized a two-step immersioncoating to zwitterionize ePTFE membranes. Thefirst coating consists of the co-deposition of polyethylenimine (PEI) and polydopamine (PDA) to produceamine groups in the surface of the ePTFE for further functionalization. Theseamine groups from PEI will be coupled with the epoxide group of thezwitterionic copolymer, poly(GMA-co-SBMA) (PGS), via a ring-openingreaction in the second coating. The coated ePTFE membranes were physicallyand chemically characterized to ensure that each step of the coating is successful. The membranes were also tested for theirthrombogenicity via quantification of the blood cells attached to it during contact with biological solutions. The coated membranesexhibited around 90% reduction in attachment with respect to the uncoated ePTFE for both Gram-positive and Gram-negativestrains of bacteria (Staphylococcus aureusandEscherichia coli). The coating was also able to resist blood cell attachment from humanwhole blood by 81.57% and resist red blood cell attachment from red blood cell concentrate by 93.4%. These ePTFE membranes,which are coated by a simple immersion coating, show significant enhancement of the biocompatibility of the membranes, whichshows promise for future use in biological devices.

Item Type:Article
Additional Information:Vero
HAL Id:hal-03030880
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Other partners > University of Akron - UA (USA)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Chung Yuan Christian University - CYCU (TAIWAN)
Other partners > Mapúa University (PHILIPPINES)
Laboratory name:
Funders:
Chung Yuan Christian University - Ministry of Science and Technology - Agence Nationale de la Recherche - National Science Foundation - Department of Science and Technology−Science Education Institute - Engineering Research and Development for Technology
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Deposited On:03 Dec 2020 09:50

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