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MRI evaluation of the hydration status of non-pathological lumbar intervertebral discs in a pediatric population

Bolzinger, Manon and Estivalèzes, Erik and Gallini, Adeline and Polirsztok, Eva and Abelin-Genevois, Kariman and Baunin, Christiane and Sales de Gauzy, Jérôme and Swider, Pascal MRI evaluation of the hydration status of non-pathological lumbar intervertebral discs in a pediatric population. (2020) Orthopaedics & Traumatology: Surgery & Research, 106 (7). 1281-1285. ISSN 1877-0568

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Official URL: https://doi.org/10.1016/j.otsr.2019.11.034

Abstract

Introduction The intervertebral disc (IVD) is made up of the annulus fibrosus (AF) and the nucleus pulposus (NP) – an inert hydrated complex. The ability of the IVD to deform is correlated to that of the NP and depends on its hydration. As the IVD ages, its hydration decreases along with its ability to deform. In adolescent idiopathic scoliosis, one of the etiological hypotheses pertains to the IVD, thus making its condition relevant for the diagnosis and monitoring of this pathology. Hypothesis IVD hydration depends on sex, age and spine level in an asymptomatic pediatric population. The corollary is data on a control group of healthy subjects. Material and methods A cohort of 98 subjects with normal spine MRI was enrolled; their mean age was 13.3 years. The disc volume and hydration of each IVD was evaluated on T2-weighted MRI sequences, using previously validated image processing software. This evaluation focused on the lumbar spine, from the thoracolumbar junction to the lumbosacral junction. It was assumed that IVD hydration was related to the ratio of NP and AF volumes. A mixed multivariate linear analysis was used to explore the impact of age, sex and spinal level on disc hydration. Results Disc hydration was higher overall in boys than in girls, but this difference was not significant. Hydration increased with age by +0.005 for each additional year (p = 0.0213). Disc hydration appears to be higher at the thoracolumbar junction than the lumbar spine, although this difference was not significant. Conclusion Through this MRI study, we established a database of non-pathological lumbar disc hydration as a function of age, sex and spinal segment along with 95% confidence intervals.

Item Type:Article
HAL Id:hal-03034231
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Centre Hospitalier Universitaire de Nancy - CHU Nancy (FRANCE)
Other partners > Centre Médico-Chirurgical de Réadaptation des Massues - CMCR des Massues (FRANCE)
Other partners > Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
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Deposited On:20 Oct 2020 09:03

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