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Carbon nanofiber-PEDOT composite films as novel microelectrode for neural interfaces and biosensing

Saunier, Valentin and Flahaut, Emmanuel and Blatché, Marie-Charline and Bergaud, Christian and Maziz, Ali Carbon nanofiber-PEDOT composite films as novel microelectrode for neural interfaces and biosensing. (2020) Biosensors and Bioelectronics, 165. 112413. ISSN 0956-5663

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Official URL: https://doi.org/10.1016/j.bios.2020.112413

Abstract

A clear need exists for novel nanostructured materials that are capable to meet the performance criteria of a number of neuronal therapies including neural recording, stimulation and sensing of bioactive molecules at the electrode-tissue interface. By combining Poly (3,4-ethylenedioxythiophene) (PEDOT), with Carbon Nanofibers (CNFs), we demonstrate a versatile approach for the synthesis of a novel composite material PEDOT:CNF withremarkable electrochemical properties, combining low impedance, high surface area, high charge injection capability and reliable neurotransmitters monitoring using amperometric techniques. The oxidized CNFs were utilized as dopants of PEDOT to prepare the composite coatings through electrochemical deposition on neuralmicroelectrodes arrays (MEA). The PEDOT:CNF modified microelectrodes demonstrated the low specificimpedance of 1.28 MΩ μm2 at 1 kHz and results in unrivalled charge injection limit of 10.03 mC/cm2 when compared to other reported organic electrode nanomaterials. Furthermore, amperometric detection performances were determined for the neurotransmitters dopamine and serotonin, exhibiting linear concentration range from 0.1 to 9 μM and from 0.06 to 9 μM respectively, high sensitivities (44.54 pA/nM.μm2 and 71.08 pA/nM.μm2, respectively) and low detection limits (0.045 μM and 0.056 μM, respectively). Cell viability was investigated on PEDOT:CNF coated microelectrodes to show that the composite material does not advocate anycytotoxicity. Taken together, these results suggest the great potential of PEDOT:CNF composite for developing next-generation multifunctional microelectrodes for applications in neural therapies.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
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Deposited On:16 Oct 2020 13:43

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