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Optimization of synchronization experiments using a checkpoint-oriented cell cycle simulator

Bernard, David and Pascalie, Jonathan and Mondésert, Odile and Ducommun, Bernard and Duthen, Yves and Cussat-Blanc, Sylvain and Lobjois, Valérie Optimization of synchronization experiments using a checkpoint-oriented cell cycle simulator. (2018) In: Toulouse Onco Week (TOW 2018), 3 February 2018 - 7 February 2018 (Toulouse, France). (Unpublished)

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Abstract

Cell cycle synchronization at a specific stage is often an essential requirement to investigate biological events and mechanisms using the large panel of molecular and cellular biology technologies. Optimization of the synchronization parameters is most of the time neglected, which could result in experimental time wasting or even in erroneous conclusions. Here we report the development of a cell cycle checkpoint-oriented simulator, based on agent-based modeling (ABM), that reproduces the dynamic behavior of a proliferating cell population and its response to checkpoint activation.

Item Type:Conference or Workshop Item (Poster)
HAL Id:hal-02947736
Audience (conference):National conference proceedings
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Université de Toulouse > Université Toulouse - Jean Jaurès - UT2J (FRANCE)
Université de Toulouse > Université Toulouse 1 Capitole - UT1 (FRANCE)
Other partners > Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
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Deposited On:09 Sep 2020 08:17

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