Parnaud, Géraldine and Taché, Sylviane and Peiffer, Ginette and Corpet, Denis E. Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice. (2001) British Journal of Cancer, 8 (1). 90-93. ISSN 0007-0920
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(Document in English)
PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 410kB |
Official URL: http://www.nature.com/bjc/journal/v84/n1/pdf/6691540a.pdf
Abstract
Polyethylene-glycol (PEG) is a strong inhibitor of colon cancer in rats, and the most potent suppressor of aberrant crypt foci. Nine PEG-like block copolymers were tested in rodents, after an azoxymethane injection. Dietary pluronic F68 led to a 98.6% reduction in the number of aberrant crypt foci in a first rat study (P < 0.0001). Next 3 studies confirmed this pluronic efficacy in rats and mice. This non-toxic laxative seems roughly five times more potent than PEG for chemoprevention.
| Item Type: | Article |
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| Additional Information: | Thanks to Nature Publishing Group. The original PDF of the article can be found at the British Journal of Cancer website : http://www.nature.com/bjc |
| Audience (journal): | International peer-reviewed journal |
| Uncontrolled Keywords: | |
| Institution: | French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE) Other partners > National Cancer Institute (USA) Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE) |
| Laboratory name: | Xénobiotiques (Toulouse, France) - Aliments & Cancer |
| Funders: | INRA of the Ministère de l’Agriculture, France - DGER of the Ministère de l’Agriculture, France - GP was supported by a studentship from the Ligue Nationale contre le Cancer, Gers, France |
| Statistics: | download |
| Deposited By: | Denis CORPET |
| Deposited On: | 05 May 2008 15:51 |
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