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CFD stimulation of gluconic acid production in a stirred gas-liquid fermenter

Elqotbi, Mohammed and Montastruc, Ludovic and Vlaev, S.D. and Nikov, Iordan CFD stimulation of gluconic acid production in a stirred gas-liquid fermenter. (2006) In: MIXING 2006 12th European Conference on Mixing Bologna, 27-30 June 2006, Bologna, Italie .

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Designing large-scale stirred bioreactors with performance closely matching the one achieved in lab-scale fermenters presents continuous challenge. In this contribution, dynamic modelling of the aerobic biocatalytic conversion process in viscous batch stirred tank reactor is developed. Its operation is illustrated by simulation of the interaction of fluid flow, mass transfer and reaction relevant to gluconic acid production by a strictly aerophilic Aspergiluc niger based on a “twofluid” model. As a result of this simulation, the velocity fields, the local substrate, dissolved oxygen, product and biomass concentration profiles were obtained. Constant bubble size and global gas-liquid mass transfer were assumed. The algorithm employed could be used for fast evaluation procedures regarding predictions and feedback control of aerobic bioreactor performance.

Item Type:Conference or Workshop Item (Paper)
Audience (conference):International conference proceedings
Uncontrolled Keywords:
Institution:Other partners > Polytech'Lille (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Université des Sciences et Technologies de Lille - USTL (FRANCE)
Laboratory name:
Deposited On:16 Jun 2009 09:30

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