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Ibuprofen loading into mesoporous silica nanoparticles using Co-Spray drying: A multi-scale study

Ruffel, Lucas and Soulié, Jérémy and Coppel, Yannick and Roblin, Pierre and Brouillet, Fabien and Frances, Christine and Tourbin, Mallorie Ibuprofen loading into mesoporous silica nanoparticles using Co-Spray drying: A multi-scale study. (2020) Microporous and Mesoporous Materials, 291. 109689. ISSN 1387-1811

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Official URL: https://doi.org/10.1016/j.micromeso.2019.109689

Abstract

Mesoporous Silica Nanoparticles (MSN) are used in an increasing number of applications in nanomedicine. Their synthesis and external/internal functionalization have been extensively studied as well as their biological properties. Nevertheless, the conventional drug loading processes of MSN (such as impregnation), do not enable sufficient efficiency and are difficult to consider on an industrial scale. To overcome these limitations, we implemented an innovative co-spray-drying process, using a nano spray-dryer, to load MSN with ibuprofen molecules. In this contribution, complementary techniques were used to perform a multi-scale characterization of the loaded particles. Spray-dried powders have been analysed from aggregates size and morphology to pore loading and ibuprofen conformation. This study demonstrates that ibuprofen/silica weight ratio in the initial suspension strongly affects the location (into mesopores or external) and the conformation (crystallized, amorphous or liquid-like) of ibuprofen. The quantification of each phase has allowed calculating precise loading rates and demonstrate tunable pore filling.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
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Deposited On:09 Mar 2020 12:21

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