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Agglomeration of stoichiometric hydroxyapatite: Impact on particle size distribution and purity in the precipitation and maturation steps

Tourbin, Mallorie and Brouillet, Fabien and Galey, Basile and Rouquet, Nicole and Gras, Pierre and Abi Chebel, Nicolas and Grossin, David and Frances, Christine Agglomeration of stoichiometric hydroxyapatite: Impact on particle size distribution and purity in the precipitation and maturation steps. (2020) Powder Technology, 360. 977-988. ISSN 0032-5910

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Official URL: https://doi.org/10.1016/j.powtec.2019.10.050

Abstract

Stoichiometric hydroxyapatite (HAP) is a prominent biomaterial, notably used as coating on metal bone prostheses. High chemical purity and a specific particle size distribution are the main properties for such an application. Based on industrial practice, a reference synthesis was first performed in a lab-scale stirred reactor. Improvements were then suggested by varying the physicochemical and hydrodynamic conditions. The shear rate within the reactor, characterized by the mean Kolmogorov micro-scale, has a strong impact on the final agglomerate size distribution. By maintaining a rather high mixing rate and a high temperature, the duration of the synthesis can be reduced considerably without affecting the HAP purity provided the pH is properly regulated. This consists of imposing acidic conditions during a short period just after the initial formation of large aggregates and then setting the pH at above 7.5 to ensure the production of pure stoichiometric HAP.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Urodelia (FRANCE)
Laboratory name:
Funders:
Agence Nationale de la Recherche - ANR - Conseil Régional Midi Pyrénées
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Deposited On:09 Mar 2020 09:41

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