Tourbin, Mallorie and Brouillet, Fabien
and Galey, Basile and Rouquet, Nicole and Gras, Pierre
and Abi Chebel, Nicolas
and Grossin, David
and Frances, Christine
Agglomeration of stoichiometric hydroxyapatite: Impact on particle size distribution and purity in the precipitation and maturation steps.
(2020)
Powder Technology, 360. 977-988. ISSN 0032-5910
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(Document in English)
PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 1MB |
Official URL: https://doi.org/10.1016/j.powtec.2019.10.050
Abstract
Stoichiometric hydroxyapatite (HAP) is a prominent biomaterial, notably used as coating on metal bone prostheses. High chemical purity and a specific particle size distribution are the main properties for such an application. Based on industrial practice, a reference synthesis was first performed in a lab-scale stirred reactor. Improvements were then suggested by varying the physicochemical and hydrodynamic conditions. The shear rate within the reactor, characterized by the mean Kolmogorov micro-scale, has a strong impact on the final agglomerate size distribution. By maintaining a rather high mixing rate and a high temperature, the duration of the synthesis can be reduced considerably without affecting the HAP purity provided the pH is properly regulated. This consists of imposing acidic conditions during a short period just after the initial formation of large aggregates and then setting the pH at above 7.5 to ensure the production of pure stoichiometric HAP.
Item Type: | Article |
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Audience (journal): | International peer-reviewed journal |
Uncontrolled Keywords: | |
Institution: | French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE) Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE) Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE) Other partners > Urodelia (FRANCE) |
Laboratory name: | |
Funders: | Agence Nationale de la Recherche - ANR - Conseil Régional Midi Pyrénées |
Statistics: | download |
Deposited On: | 09 Mar 2020 09:41 |
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