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Development of antimicrobial composite coatings for drug release in dental, orthopaedic and neural prostheses applications

Macha, Innocent J. and Karacan, Ipek and Ben-Nissan, Besim and Cazalbou, Sophie and Müller, Wolfgang H. Development of antimicrobial composite coatings for drug release in dental, orthopaedic and neural prostheses applications. (2019) SN Applied Sciences, 1 (1). ISSN 2523-3963

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Official URL: https://doi.org/10.1007/s42452-018-0064-1

Abstract

While one of the major clinical and scientific challenges in the management of implant-related infections and post-operative complications after surgery is the application of new techniques, a new approach is pertinent in the design of medical implants to reduce bacterial infections. We have designed and tested antibiotic-containing biocomposite thin films of polylactic acid (PLA), and coralline-derived hydroxyapatite (HAp) as controlled drug delivery systems for the treatment of dental, orthopaedic and neural implant-related post-operative infections. These films can be applied to complicated designs of dental, miniaturized neural devices, cochlear or total hip replacement (THR) implants by spray or dip-coating techniques. Current results reveal that the devices could release antibiotic in a controlled manner to prevent significantly bacterial growth and biofilm production. Hydroxyapatite within the composites controls the release rate and also supplies minerals, such as calcium Ca2+ and phosphate PO42− ions, which are essential minerals for bone tissue regeneration. It is concluded from the physical, mechanical and biological properties that these coatings and devices could easily be utilized in a wide range of biomedical applications.

Item Type:Article
HAL Id:hal-02498506
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Other partners > Technische Universität Berlin - TU Berlin (GERMANY)
Other partners > University of Dar es Salaam (TANZANIA)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > University of Technology, Sydney - UTS (AUSTRALIA)
Laboratory name:
Funders:
Australian Academy of Science - European Union’s Horizon 2020
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Deposited On:04 Mar 2020 14:10

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