OATAO - Open Archive Toulouse Archive Ouverte Open Access Week

Development of antimicrobial composite coatings for drug release in dental, orthopaedic and neural prostheses applications

Macha, Innocent J. and Karacan, Ipek and Ben-Nissan, Besim and Cazalbou, Sophie and Müller, Wolfgang H. Development of antimicrobial composite coatings for drug release in dental, orthopaedic and neural prostheses applications. (2019) SN Applied Sciences, 1 (1). ISSN 2523-3963

(Document in English)

PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader

Official URL: https://doi.org/10.1007/s42452-018-0064-1


While one of the major clinical and scientific challenges in the management of implant-related infections and post-operative complications after surgery is the application of new techniques, a new approach is pertinent in the design of medical implants to reduce bacterial infections. We have designed and tested antibiotic-containing biocomposite thin films of polylactic acid (PLA), and coralline-derived hydroxyapatite (HAp) as controlled drug delivery systems for the treatment of dental, orthopaedic and neural implant-related post-operative infections. These films can be applied to complicated designs of dental, miniaturized neural devices, cochlear or total hip replacement (THR) implants by spray or dip-coating techniques. Current results reveal that the devices could release antibiotic in a controlled manner to prevent significantly bacterial growth and biofilm production. Hydroxyapatite within the composites controls the release rate and also supplies minerals, such as calcium Ca2+ and phosphate PO42− ions, which are essential minerals for bone tissue regeneration. It is concluded from the physical, mechanical and biological properties that these coatings and devices could easily be utilized in a wide range of biomedical applications.

Item Type:Article
HAL Id:hal-02498506
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Other partners > Technische Universität Berlin - TU Berlin (GERMANY)
Other partners > University of Dar es Salaam (TANZANIA)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > University of Technology, Sydney - UTS (AUSTRALIA)
Laboratory name:
Australian Academy of Science - European Union’s Horizon 2020
Deposited On:04 Mar 2020 14:10

Repository Staff Only: item control page