Taché, Sylviane and Ladam, Aélis and Corpet, Denis E. Chemoprevention of aberrant crypt foci in the colon of rats by dietary onion. (2007) European Journal of Cancer, 4 (2). 454-458. ISSN 0959-8049
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(Document in English)
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Official URL: http://dx.doi.org/10.1016/j.ejca.2006.09.022
Abstract
Onion intake might reduce the risk of colorectal cancer, according to epidemiology. However, Femia showed in 2003 that diets with a 20% onion intake increase carcinogenesis in rats. We speculated this dose was too high. Prevention of initiation was thus tested in 60 rats given a 5% dried onion diet or AIN76 diet, and initiated 12 days later with azoxymethane (AOM, 1 × 20 mg/kg i.p.), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ, 2 × 200 mg/kg p.o.), or N-nitroso–N–methylurea (2 × 50 mg/kg p.o.). Prevention of promotion was tested in 38 rats given AOM, then randomised to: AIN76 diet; 5% onion diet; phytochemicals diet (supplemented with propyl-disulfide, quercetine-glycosides and oligofructose); 1% pluronic F68 diet (a potent chemopreventive PEG-like block-polymer, used as a positive control). Aberrant crypt foci (ACF) were scored 30 days (initiation) or 100 days (promotion) after carcinogen injection. The onion diet given during initiation reduced the number of AOM-induced ACF (60 versus 86, p = 0.03), and the size of IQ-induced ACF (1.33 versus 1.97, p = 0.02). Given post-initiation, the onion diet reduced the number of ACF (34 versus 59, p = 0.008) and of large ACF (6 versus 15, p = 0.02). Phytochemicals diet and pluronic diet reduced ACF growth similarly. Data show that a 5% onion diet reduced carcinogenesis during initiation and promotion stages, and suggest this chemoprevention is due to known phytochemicals.
Item Type: | Article |
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Additional Information: | Author can archive post-print but not original PDF. Thanks to Elsevier ScienceDirect : http://www.sciencedirect.com/science/journal/09598049 |
Audience (journal): | International peer-reviewed journal |
Uncontrolled Keywords: | Colon cancer - Chemoprevention - Aberrant crypt foci - Onion - Phytochemicals - Rats - Quercetin - Sulfides - Allium
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Institution: | French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE) Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE) |
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Deposited On: | 18 Apr 2008 09:03 |
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