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Biomechanical response of the CNS is associated with frailty in NPH-suspected patients

Vallet, Alexandra and Del Campo, Natalia and Hoogendijk, Emiel O. and Lokossou, Armelle and Balédent, Olivier and Czosnyka, Zofla and Balardy, Laurent and Payoux, Pierre and Swider, Pascal and Lorthois, Sylvie and Schmidt, Eric Biomechanical response of the CNS is associated with frailty in NPH-suspected patients. (2020) Journal of Neurology, 267. 1389-1400. ISSN 0340-5354

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Official URL: https://doi.org/10.1007/s00415-019-09689-z

Abstract

Frailty is known to predict dementia. However, its link with neurodegenerative alterations of the central nervous system (CNS) is not well understood at present. We investigated the association between the biomechanical response of the CNS and frailty in older adults suspected of normal pressure hydrocephalus (NPH) presenting with markers of multiple co-existing pathologies. The biomechanical response of the CNS was characterized by the CNS elastance coefficient inferred from phase contrast magnetic resonance imaging and intracranial pressure monitoring during a lumbar infusion test. Frailty was assessed with an index of health deficit accumulation. We found a significant association between the CNS elastance coefficient and frailty, with an effect size comparable to that between frailty and age, the latter being the strongest known risk factor for frailty. Results were independent of CSF dynamics, showing that they are not specific to the NPH neuropathological condition. The CNS biomechanical characterization may help to understand how frailty is related to neurodegeneration and detect the shift from normal to pathological brain ageing.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Other partners > University of Cambridge (UNITED KINGDOM)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Université de Picardie Jules Verne (FRANCE)
Other partners > Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
Laboratory name:
Funders:
Groupement Interrégional de Recherche Clinique et d’Innovation Sud-Ouest Outre- Mer Hospitalier - Occitania Région - ERC Consolidator BrainMicroFlow
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Deposited On:06 Mar 2020 11:05

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